Diclofenac Diethyl Amine Salt

Diclofenac Diethyl Amine Salt - Names and Identifiers

Name	Diclofenac Diethylamine
Synonyms	DICLOFENAC DIETHYLAMINE Diclofenac Diethylamine Diclofenac Diethyl Amine Salt Diclofenac diethyl ammonium salt 2-[2-(2,6-dichloroanilino)phenyl]acetic acid N-Ethylethanamine 2-[(2,6-dichlorophenyl)amino]benzeneacetate n-ethylethanamine 2-[(2,6-dichlorophenyl)amino]benzeneacetate 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid compd. with n-ethylethanamine
CAS	78213-16-8
EINECS	616-599-2
InChI	InChI=1/C14H11Cl2NO2.C4H11N/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;1-3-5-4-2/h1-7,17H,8H2,(H,18,19);5H,3-4H2,1-2H3

Diclofenac Diethyl Amine Salt - Physico-chemical Properties

Molecular Formula	C18H22Cl2N2O2
Molar Mass	369.29
Melting Point	145-148°C
Boling Point	412°C at 760 mmHg
Flash Point	203°C
Solubility	Soluble in DMSO (74 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), and ethanol (< 1
Vapor Presure	1.59E-07mmHg at 25°C
Storage Condition	Inert atmosphere,Room Temperature
In vitro study	The main mechanism of action of Diclofenac diethylamine's anti-inflammatory, antipyretic, and analgesic effects is thought to be through inhibition of cyclooxygenase (COX), thereby inhibiting prostaglandin synthesis. It exerts bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also reduces prostaglandins in gastric epithelial cells, making them more susceptible to corrosion by stomach acid. This is also the main side effect of diclofenac diethylamine. Diclofenac diethylamine blocks the cox2-isozyme (about 10-fold) with low to moderate selectivity, thus causing a lower incidence of gastrointestinal disorders than indomethacin and aspirin.

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View History

Diclofenac Diethyl Amine Salt
57029-18-2