Diclofenac Diethyl Amine Salt
Diclofenac Diethylamine
CAS: 78213-16-8
Molecular Formula: C18H22Cl2N2O2
Diclofenac Diethyl Amine Salt - Names and Identifiers
| Name | Diclofenac Diethylamine |
| Synonyms | DICLOFENAC DIETHYLAMINE Diclofenac Diethylamine Diclofenac Diethyl Amine Salt Diclofenac diethyl ammonium salt 2-[2-(2,6-dichloroanilino)phenyl]acetic acid N-Ethylethanamine 2-[(2,6-dichlorophenyl)amino]benzeneacetate n-ethylethanamine 2-[(2,6-dichlorophenyl)amino]benzeneacetate 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid compd. with n-ethylethanamine |
| CAS | 78213-16-8 |
| EINECS | 616-599-2 |
| InChI | InChI=1/C14H11Cl2NO2.C4H11N/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;1-3-5-4-2/h1-7,17H,8H2,(H,18,19);5H,3-4H2,1-2H3 |
Diclofenac Diethyl Amine Salt - Physico-chemical Properties
| Molecular Formula | C18H22Cl2N2O2 |
| Molar Mass | 369.29 |
| Melting Point | 145-148°C |
| Boling Point | 412°C at 760 mmHg |
| Flash Point | 203°C |
| Solubility | Soluble in DMSO (74 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), and ethanol (< 1 |
| Vapor Presure | 1.59E-07mmHg at 25°C |
| Storage Condition | Inert atmosphere,Room Temperature |
| In vitro study | The main mechanism of action of Diclofenac diethylamine's anti-inflammatory, antipyretic, and analgesic effects is thought to be through inhibition of cyclooxygenase (COX), thereby inhibiting prostaglandin synthesis. It exerts bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also reduces prostaglandins in gastric epithelial cells, making them more susceptible to corrosion by stomach acid. This is also the main side effect of diclofenac diethylamine. Diclofenac diethylamine blocks the cox2-isozyme (about 10-fold) with low to moderate selectivity, thus causing a lower incidence of gastrointestinal disorders than indomethacin and aspirin. |
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